Nanotechnologie česká verze
  BITCOIN
Program „Nanotechnology for the Society“ (code KA)
Vydáno dne 23. 10. 2008 (3839 přečtení)

List of researched projects accepted within the 1st round of the public tender. There have been the following projects accepted within the first round of the public tender for solution in the period from 1 July 2006 to December 2010:

SUBPROGRAMME 1: Nanoparticles, nanofibres and nanocomposite materials

KAN100500651 “Preparation and studies of organic-inorganic nanocomposite material properties prepared in situ by the emulsive polymerisation”, 07/2006-12/2009, the head researcher is Ing. Zdeňka Sedláková, CSc, Institute of Macromolecular Chemistry of AS CR, the total costs of CZK 4.193 million, thereof CZK 3.563 million from the state budget. (Year 2008 – 1.175/0.995, 1g)

Co-researchers:
- Institute of Inorganic Chemistry AS CR, Řež, Ing. Kamil Lang, CSc.
- Charles University in Praha, Faculty of Mathematics and Physics, RNDr. Ivan Krakovský, CSc.
- Institute of Chemical Technology Praha, Faculty of Chemical Technology, Doc. Ing. František Kovanda, CSc.
- Hexion Specialty Chemicals, a.s., Sokolov, Ing. Jan Nájemník
Objective of the solution: The knowledge gained in the basic research allows for the targeted preparation of watery dispersions of polymers of unique properties. The dispersions are based on new nanocomposite polymers containing chemically bound inorganic nanomaterials. The industrial partner develops, in parallel with results of the basic research and within his own internal projects, dispersion prototypes. Thanks to the defined nanocomposite materials’ architecture containing particles smaller than 100 nm, the prototypes should have unique properties suitable for the manufacture of adhesives and paints (e.g. antibacterial effects, the higher dirt resistance, the better stickiness and hardness). There are new preparation methods and characterising of new dual layer hydroxides developed within the project for the preparation of nanocomposite materials. There are also properties of the developed nanocomposite materials studied and the management of these properties is verified by adding selected additives, e.g. photosensitive substances.

KAN100500652 “Heterogenous organic and hybrid nanocomposite materials for solar cells”, 07/2006-12/2010, the head researcher is RNDr. Jiří Pfleger, CSc., Institute of Macromolecular Chemistry of AS CR, the total costs of CZK 27.493 million, thereof CZK 22.993 million from the state budget. (Year 2008 – 3.953/2.871, 1g)

Co-researchers:
- J. Heyrovsky Institute of Physical Chemistry of AS CR, Praha, Doc. RNDr. Svatopluk Civiš, CSc.
- Charles University in Praha, Faculty of Science, Prof. RNDr. Jiří Vohlídal, CSc.
- Solartec, s.r.o., Rožnov pod Radhoštěm, Dr. Ing. Aleš Poruba.
Objective of the solution: The gain of complex knowledge allowing the targeted proposal of nanostructured materials of the nanocomposite p-conjugated polymers and metal oxides’ types for optoelectronic applications, especially for photoelectrochemical and solid solar cells. The molecular architecture and morphology are optimised by the combination of chemical processes and physical phenomena, e.g. by the spontaneous phase separation and crystallisation in the matrix. The relation between the chemical and super molecular structure and usable physical properties are experimentally studied and consequently theoretically modelled. Then, it is utilised for the optimising of the chemical structure. The partial project objectives are (i) the development of new photoelectrically sensitive materials, (ii) the study of relations between their structure and electric and optical properties, and (iii) the utilisation of gained knowledge for proposals of new kinds of organic solar cells and for the improvement of functional parameters of cells based on the traditional inorganic materials.

KAN101630651 “Creation of nano-layers and nano-coatings on textiles with the use of surface plasma treatment under atmospheric pressure”, 07/2006-12/2010, the head researcher is Prof. RNDr. Mirko Černák, CSc., Masaryk University, Faculty of Science, Brno, the total costs of CZK 41.855 million, thereof CZK 33.810 million from the state budget. (Year 2008 – 8.591/6.952, 1d)

Co-researchers:
- Palacky University Olomouc, Faculty of Science, Prof. RNDr. Miroslav Mašláň, CSc.
- Technical University in Liberec, Faculty of Textiles, Ing. Jakub Wiener, PhD.
- Textile Testing Institute, s.p., Brno, RNDr. Pavel Malčík
- Lifetech s.r.o., Brno, Doc. RNDr. Jiří Dřímal, CSc.
Objective of the solution: The research of utilisation possibilities related to the low-temperature plasma generated at the atmospheric pressure for the creation of nanolayers and nanocoatings on the surface of textile fibres. The plasma is generated during the utilisation of new unique plasma resource kinds with the potential of a successful application in the textile industry. The focus is put on the understanding of the mechanism of the plasma activation of nanolayers on fibre surfaces, on the interaction of in this way by the plasma activated surfaces with nanopowders, and on the methods creating nanolayers without the use of organic solvents and other environmentally harmful chemicals. The goal of the surface nanotreatments is the gaining of new utility properties of textile materials suitable, for example, for the protection of the environment and workplaces.

KAN108040651 “Research of the manufacturing and the utilisation of nanoparticles based on zero-valent iron for the treatment of contaminated underground waters”, 07/2006-12/2008, the head researcher is Doc. Dr. Ing. Miroslav Černík, CSc., Technical University in Liberec, Faculty of Mechatronics and Interdisciplinary Engineering Studies, the total costs of CZK 26.350 million, thereof CZK 21.903 million from the state budget. (Year 2008 – 10.199/8.520, 1a)

Co-researchers:
- Palacky University Olomouc, Faculty of Science, Doc. RNDr. Radek Zbořil, PhD.
- Masaryk University, Faculty of Science, Brno, Doc. RNDr. Josef Zeman, CSc.
- AQUATEST a.s., Praha, RNDr. Petr Kvapil, PhD.
Objective of the solution: The development and the manufacture of a new nanomaterial based on the surface modified iron nanoparticles having specific properties for the use in oxidation-reduction reactions resulting in the removal of specific underground water contaminants (chlorinated hydrocarbons, heavy metals) and creating non toxic or significantly less toxic products. The in-depth research and optimising of properties of this nanomaterial make a part of the solution. It will utilise the most advanced equipment and laboratory experiments revealing the reactions with selected contaminants and competing substances. The goal is the proposal, laboratory testing, and semi-operational testing of the manufacture of these nanoparticles. The resulting product will be experimentally verified in at least two pilot applications. The proposed precursors for the manufacture are the waste materials gained during the extraction of minerals or in the chemical production. The project should thus ensure the cheap and economically liable end product.


SUB PROGRAMME 2: Nanobiology and nanomedicine

KAN200040651 “Electrochemical and optical analyses of biomacromolecules on microelectrodes covered with nanolayers of electroactive materials”, 07/2006-12/2010, the head researcher is Mgr. Stanislav Hasoň, PhD., Institute of Biophysics of AS CR, Brno, the total costs of CZK 7.259 million, thereof CZK 6.529 million from the state budget. (Year 2008 – 1.552/1.396, 3e)

Co-researchers:
- HVM Plasma, spol. s r.o., Praha, Ing. Jiří Vyskočil, CSc.
Objective of the solution: The clarification of relations between the structure of biomacromolecules (nucleic acids, chemically modified oligonucleotides, or proteins) and their electrochemical behaviour on the electrically charged surfaces of new electrode materials the properties and behaviour of which are decisively determined by their surfaces and/or by their nanometric structure. The introduction of modern electroanalytical approaches in combination with diffractive and spectroscopic methods for the targeted creation of the beforehand defined nanometric layers of biomacromolecules with the use of modern nanostructures contributing to the development of simple and selective biosensors for the electrochemical detection of nucleic acids, hybridisation and DNA damage, or for the detection of their interactions with for genes toxic materials. The clarification of the adsorption behaviour and the structure of adsorbed protein layers on surfaces of advanced materials suitable for biomedicine and bioengineering, according to their surface treatment and the changed external physical-chemical parameters.

KAN200200651 “Nanoparticle and supramolecular systems for the targeted transport of medication”, 07/2006-12/2010, the head researcher is Prof. RNDr. Blanka Říhová, DrSc., Institute of Microbiology of AS CR, Praha, the total costs of CZK 93.560 million, thereof CZK 81.560 million from the state budget. (Year 2008 – 17.905/14.905, 3b)

Co-researchers:
- Institute of Biophysics of AS CR, Brno, Prof. RNDr. Viktor Brabec, DrSc.
- Palacky University Olomouc, Faculty of Medicine, Prof. RNDr. Pavel Anzenbacher, DrSc.
- Institute of Chemical Technology Praha, Faculty of Chemical Engineering, Prof. RNDr. Vladimír Král, CSc.
- Charles University in Praha, Faculty of Science, Doc. Ing. Josef Hájíček, CSc.
- Charles University in Praha, 1st Faculty of Medicine, Prof. MUDr. Pavel Martásek, DrSc.
- Institute of Organic Chemistry and Biochemistry of AS CR, Praha, RNDr. Ladislav Kohout, DrSc.
- Institute of Molecular Genetics of AS CR, Praha, RNDr. Jarmila Králová, PhD.
- Institute of Macromolecular Chemistry of AS CR, Praha, Prof. Ing. Karel Ulbrich, DrSc.
- Institute of Physics of AS CR, Praha, Doc. Ing. Emil Pollert, DrSc.
- Zentiva a.s., Praha, Ing. Jan Šotola, CSc.
Objective of the solution: The development of a new generation of nanopharmaceuticals, medicine, the directional systems medicine, and magnetic nanoparticles for diagnostic and nanotherapeutical purposes. Analytical techniques confirming the composition, stability and connection with the targeted biomacromolecules make parts of the project.

KAN201110651 “Combined contrast agents for the molecular MR imaging”, 07/2006-12/2010, the head researcher is Prof. RNDr. Ivan Lukeš, CSc., Charles University in Praha, Faculty of Science, the total costs of CZK 38.371 million, thereof CZK 32.136 million from the state budget. (Year 2008 – 6.832/5.632, 3e)

Co-researchers:
- Institute of Experimental Medicine of AS CR, Praha, Prof. MUDr. Eva Syková, DrSc.
- Institute of Clinical and Experimental Medicine, Praha, Ing. Milan Hájek, DrSc.
- Interpharma Praha, a.s., Ing. Ivan Hlaváček, CSc.
Objective of the solution: The proposal and the synthesis of new ligand types, the preparation of their complexes with metallic ions, and the testing of their stability for the in vivo use. The verification of their suitability for the preparation of positive cell contrast substances mostly on the basis of gadolinium (the tune up of parameters at the molecular level). The creation of a combined contrast substance for the cell imagining based on the combination of simple gadolinium complexes and oxide nanoparticles or on their conjugates with dendrimers allowing the monitoring of both positive and negative contrasts. The verification of biological and relaxometric properties of the new synthetised compounds. The application of these contrast substances within the monitoring of stem cells. The finding out, if changes in the contrast are effective during examinations done by the whole body clinical tomographs working at 1.5 and 3 T.

KAN208240651 “Studies of interactions of biological macromolecules and nanolayers focussed on the research of polymeric microfluid biosensors and therapeutic nanoparticles”, 07/2006-12/2010, the head researcher is Doc. Ing. Pavel Hasal, CSc., Institute of Chemical Technology Praha, the total costs of CZK 19.986 million, thereof CZK 17.458 million from the state budget. (Year 2008 – 2.756/2.401, 4b)

Co-researchers:
- Apronex s.r.o., Jesenice u Prahy, RNDr. Vladimír Kořínek, CSc.
Objective of the solution: The research of highly integrated microfluid devices (biosensors) based on the detection of biologically specific components in a sample with the assistance of immobilised protein nanolayers and the research of organisation of macromolecular nanostructures, protein nanolayers and the retroviral capsids for diagnostic and therapeutic purposes. The partial project goals are as follows: the construction of suitable microfluid chips, the creation of biologically active nanolayers inside structural chips, the characterising of space and electric properties of the immobilised nanolayers and polymer carriers, the characterising of nanoparticles carrying a therapeutic gene at the nanolevel, the possible utilisation of the electrokinetic transport for the sample dosing, the testing of chips as the sensors in varied model and practically usable immunoanalytical systems, the testing of the parallel determination of varied analytes on biosensors, and the optimising of the used proteins’ structure.


SUB PROGRAMME 3: Nano-macro interface

KAN300430651 “Nanocrystallisation of plasma sprayed coatings based on eutectic ceramic mixtures”, 7/2006-12/2009, the head researcher is Ing. Tomáš Chráska, PhD., Institute of Plasma Physics of AS CR, Praha, the total costs of CZK 8.942 million, thereof CZK 7.769 million from the state budget. (Year 2008 – 1.503/1.403, 1f)

Co-researchers:
- Institute of Inorganic Chemistry AS CR, Řež, Doc. Ing. Jiří Hostomský, CSc.
- EUTIT s.r.o., Mariánské Lázně, Vladimír Havlíček
Objective of the solution: The utilisation of the plasma spray technology for the creation of bulk and graduated nanocrystalline elements of excellent properties. The use of the unique WSP(R) plasmotron for the application of the material based on eutectic mixtures of Al, Zr, and Si oxides for the preparation of 3D elements having the nanocrystalline structure. The final project’s goal is the proposal and optimising of the technology utilising the WSP(R) plasmotron for the preparation of nanocrystalline ceramic elements or thick graduated coats with the nanocrystalline structured surface. The mechanical properties of these products should overcome the current limits in the use of convention large grain materials. The following basic questions must be answered for the successful goal achievement: - the influence of a change in the individual oxidation parts’ ratio on the occurrence of an amorphous structure, after spraying; - the role of individual parts as the nucleating agents in the consequently managed crystallisation; - the grain boundaries character and their impact on the resulting material properties.


SUB PROGRAMME 4: New phenomena and materials for nanoelectronics

KAN400100652 “Structures for spintronics and quantum phenomena in nanoelectronics created with the electron beam lithography”, 7/2007-12/2010, the head researcher is Ing. Ludvík Smrčka, DrSc., Institute of Physics of AS CR, Praha, the total costs of CZK 54.438 million, thereof CZK 54.438 million from the state budget. (Year 2008 – 7.042/7.042, 2a)

Co-researchers:
- Charles University in Praha, Faculty of Mathematics and Physics, Prof. RNDr. Václav Holý, CSc.
- Czech Technical University in Praha, Faculty of Electrical Engineering, Doc. RNDr. Jan Voves, CSc.
Objective of the solution: a) The study of the tunnel anisotropic magnetoresistance (TAMR) in diluted magnetic semiconductors of the (GaMn)As type through the creation of oriented one-size channels (“nanoconstrictions”) with the resulting development of parts for spintronics; b) The research of nanodiamond structures growing in the lithographically treated substrates by the CVD method; c) The creation of homogenous fields of quantum dots on lithographically treated bases and the research of their growth by the GISAXS and GID methods. The structures used in the research are created by the newly installed electron beam lithography.

KAN400100653 “Self-organised magnetic nanostructures”, 7/2007-12/2010, the head researcher is Ing. Ján Lančok, PhD., Institute of Physics of AS CR, Praha, the total costs of CZK 54.521 million, thereof CZK 54.521 million from the state budget. (Year 2008 – 10.190/10.190, 2d)

Co-researchers:
- Institute of Inorganic Chemistry AS CR, Řež, Ing. Adriana Lančok, PhD.
- Charles University in Praha, Faculty of Mathematics and Physics, Prof. RNDr. Vladimír Sechovský, DrSc.
- VŠB - Technical University of Ostrava, Faculty of Mining and Geology, Doc. Mgr. Kamil Postava, Dr.
Objective of the solution: The preparation of nanocomposite (NC) materials containing magnetic nanoparticles (NP), e.g. FePt, CoFe, Co, and Fe, with the methods of pulse laser deposition, magnetron sputtering, the plasma jet , or by combinations of these techniques. There is the self-assembly method used for this, together with the use of a thin crystalline nucleic interlayer. The attention is turned to the research of impacts of this interlayer’s properties on the NP growth, its size, distribution, mutual distance, crystalline structure, and the crystalline orientation with the goal of their management. The structural properties of the NC layer are researched with a wide spectrum of techniques focussed on the morphology and crystalline nature. Consequently, there are magnetic and electric properties studied with the stress put on the coercivity, magnetic anisotropy, magnetoresistance, and magnetooptic properties. In final project stages, the attention will be turned to the preparation of 3D nanostructures and on the preparation of functional multistructures.

KAN400310651 “Nanotechnology for the protein and gene diagnostics”, 8/2007-12/2010, the head researcher is Ing. František Foret, CSc., Institute of Analytical Chemistry of AS CR, Brno, the total costs of CZK 18.013 million, thereof CZK 18.013 million from the state budget. (Year 2008 – 3.600/3.600, 3g)

Co-researchers:
- Institute of Biophysics of AS CR, Brno, Prof. RNDr. Emil Paleček, DrSc.
Objective of the solution: The basic research of nanostructured surfaces for the electronic detection of biochemical interactions. There will be the experience and know-how of both partners’ laboratories utilised for the start of the new research direction based on new DNA and protein analytical methods with the use of nanotechnologies, microfluidity, and electrochemistry. The preparation and characterising of nanostructures focus on the generating of an analytical signal, strengthened by the surface, with the use of nanoporous substrates, magnetic nanoparticles, and carbon nanotubes. There are also self-assembled monolayers with the surfaces modified by Au, Hg, or amalgams for the electrochemical detection utilised. These nanostructures will be used for the immobilisation of detection probes, for the research of the surface treatment impacts on chemical interactions, and for the improved sensitivity and selectivity of the detection. The use is oriented mostly on biosensors detecting DNA damage and on the research of proteins important during the progression of neurodegenerative diseases and cancer.

KAN400400651 “Experimental and theoretical studies of free nanoparticles: "Flying nanoreactors" for the research of processes taking place at the molecular level”, 7/2007-12/2010, the head researcher is Mgr. Michal Fárník, Dr., J. Heyrovsky Institute of Physical Chemistry of AS CR, Praha, the total costs of CZK 7.527 million, thereof CZK 7.527 million from the state budget. (Year 2008 – 1.075/1.075, 1a)

Co-researcher:
- Institute of Chemical Technology Praha, FCHT, RNDr. Petr Slavíček, PhD.
Objective of the solution: The preparation of free nanoparticles with the targeted management of their sizes and compositions and the experimental and theoretical studies of these nanoparticles at the molecular level. The basic idea relates to their utilisation as nanoreactors useful for the study of physical and chemical processes taking place in them. The works are topically focussed on nanoparticles and processes of the atmospheric relevance, e.g. photolysis and hydrolysis of halogen-hydrogens and other molecules on water nanoparticles which contribute to the creation of the ozone hole. The studies of interactions of the free nanoparticles with surfaces should also provide information for the creation of nanostructures on surfaces of deposited nanoparticles, in addition to the above-presented objective.

KAN400670651 “Research of the interface of metallic nanoparticles with InP for the monitoring of undesirable substances, gases and radiation in the environment”, 7/2006-12/2008, the head researcher is RNDr. Jiří Zavadil, CSc., Institute of Photonics and Electronics of AS CR, Praha, the total costs of CZK 6.264 million, thereof CZK 6.264 million from the state budget. (Year 2008 – 2.430/2.430, 1a)

Co-researcher:
- Czech Technical University in Praha, Faculty of Nuclear and Physical Engineering, Ing. Anton Fojtík, CSc.
Objective of the solution: The finding of new repeatable processes preparing the interface of an organised metallic nanoparticle/InP presenting improved properties for the utilisation in gas sensors and in the roentgen radiation detecting devices. The samples with the interface of the metallic nanoparticle/InP are prepared by the electroless plating and by the electrophoresis of metallic nanoparticles from varied colloid solution forms. There are metallic Cu, Au, Ag, Pt, and Pd nanostructures studied and prepared. There will be microscopic, electric and optical methods and the SIMS analysis used for the characterising of the nanostructures and their interfaces. The study will deal with the correlation between the arrangement rate of metallic nanoparticles’ structures and the electric properties of the interfaces, especially with the level of the potential barrier and the lost current. There will be the sensitivity of diode sensors with the prepared interface studied to the low concentration of hydrogen gas in the air and to nitrogen oxides. The research of structures detecting the roentgen radiation focuses on the better sensitivity and improved noise properties.

KAN401770651 “Molecular nanosystems and nanodevices: electric transport properties”, 7/2007-12/2010, the head researcher is Ing. Martin Weiter, PhD., Brno University of Technology, Faculty of Chemistry, the total costs of CZK 29.306 million, thereof CZK 27.806 million from the state budget. (Year 2008 – 3.703/3.703, 3d)

Co-researchers:
- Institute of Physics of AS CR, Praha, Ing. Irena Kratochvílová, PhD.
- Institute of Macromolecular Chemistry of AS CR, Praha, Prof. RNDr. Stanislav Nešpůrek, DrSc.
- GENERI BIOTECH s.r.o., Hradec Králové, Mgr. Martin Bunček, PhD.
Objective of the solution: The experimental and theoretical research of properties of molecular materials, DNA, and bioanalogical materials suitable for nanodevices. It is about the finding of physical characteristics of the studied substances, e.g. the generation and transport of the charge carrier, conductivity, optical absorption, photoluminescence, the transistor effect, the catching and recombination of carriers. There will be effort to define repeatable processes creating samples with the defined conductivity and to design technologies which could be utilised in nanoelectronics. The achievement of a progress in the preparation of nanoelectronic elements will be accompanied with measurements of individual molecule samples, or of molecule beams, with the stress put on derivates of DNA molecules. There is the preparation of theoretical models of the electron transport of charge carriers planned in the studied systems as well as the application of the models, when describing the transport in molecular wires.

Review of the public tender 1st round results

Sub programme 1 Sub programme 2 Sub programme 3 Sub programme 4 TOTAL
Number in the tender submitted proposals 9 11 4 15 39
Number of projects accepted within the programme 4 4 1 6 15
Success rate (in %) 44.4 36.4 25 40 38.5
Recognised costs of accepted projects within the research period (in thousand CZK) 99 891 158 930 8 942 169 449 437 212
Target-oriented support of accepted projects within the research period (in thousand CZK) 82 269 137 437 7 769 167 949 395 424
Average share of the target-oriented support in recognised costs (in %) 82.4 86.5 86.9 99.1 90.4


List of projects accepted for solution within the 2nd round of the public tender. There have been the following projects accepted within the 2nd round of the public tender for solution in the period from 1 January 2007 to December 2011:

SUB PROGRAMME 1: Nanoparticles, nanofibres and nanocomposite materials

KAN100400701 “Hybrid nanocomposite materials”, 01/2007-12/2011, the head researcher is Prof. Ing. Jiří Čejka, DrSc., J. Heyrovsky Institute of Physical Chemistry of AS CR, Praha, the total costs of CZK 18.75 million, thereof CZK 15.5 million from the state budget. (Year 2008 – 3.750/3.000, 1g)

Co-researchers:
- Tomáš Baťa University in Zlín, Faculty of Technology, Ing. Dana Měřínská, PhD.
- Výzkumný ústav anorganické chemie, a.s., Ústí nad Labem, RNDr. Vojtěch Varga
- KAUČUK, a.s., Kralupy nad Vltavou, Ing. Jiří Reiss, CSc.
Objectives of the solution: The research, development and the utilisation of new types of hybrid (organic - organic-metallic - inorganic) nanocomposite materials for special applications in the catalytic preparation of new polymers and the substantial improvement of properties of these polymer materials. Nanocomposite materials are willingly synthetised and their properties are optimised within the combination with classical, microwave and electrochemical approaches. Consequently, they will be characterised in detail with the use of a number of experimental techniques. The main attention will be paid during the research of these advanced nanocomposite materials to their utilisation in highly selective catalytic processes of the polymerisation type, exchange polymerisation type, and in the polymer composite materials. The gained experimental results will be utilised for the optimising of existing polymerisation processes and of the targeted products.

KAN100400702 “Nanostructural materials for the catalytic, electrocatalytic and sorption applications”, 01/2007-12/2011, the head researcher is Prof. RNDr. Zdeněk Samec, DrSc., J. Heyrovsky Institute of Physical Chemistry of AS CR, Praha, the total costs of CZK 41.664 million, thereof CZK 40.792 million from the state budget. (Year 2008 – 7.961/6.541, 1a)

Co-researchers:
- Institute of Inorganic Chemistry AS CR, Řež, Ing. Ivo Jakubec, CSc.
- Charles University in Praha, Faculty of Mathematics and Physics, Prof. RNDr. Vladimír Matolín, DrSc.
- Nuclear Research Institute Řež, a.s., Ing. Jiří Rais, CSc., DSc.
- Eurosupport Manufacturing Czechia, s.r.o., Litvínov, Ing. Milan Říčánek, CSc.
Objectives of the solution: (a) The design of preparation methods for new nanostructure and nanocomposite materials based on unique properties of metallic (alloy) nanoparticles and (mixture) metallic oxides and their interaction with inorganic carriers; (b) The gaining of system data related to the function principle of these materials in catalytic, electrocatalytic and sorption applications; (c) The extension of the spectrum of in the industry usable technologies used in the material manufacture in the Czech Republic by the transfer of knowledge. These materials will be structured in a targeted way for environmentally acceptable chemical technologies related to the areas of fuel, energy resources, and removal of pollutants; It will be, however, mainly focussed on the catalytic transformation of n-alkanes to iso-alkanes, the electrocatalytic oxidation of aliphatic alcohols in fuel cells, and sorption processes for the removal of radionuclides with the long apparent half-life (Cs, Sr, Eu, Am) from medium-term and low-active nuclear waste.

KAN101120701 “Nanocomposite layers and nanoparticles created in the low pressure plasma for surface modifications”, 01/2007-12/2011, the head researcher is Prof. RNDr. Hynek Biederman, DrSc., Charles University in Praha, Faculty of Mathematics and Physics, the total costs of CZK 50.992 million, thereof CZK 40.792 million from the state budget. (Year 2008 – 10.000/8.000, 1d)

Co-researchers:
- Institute of Physiology of AS CR, Praha, MUDr. Lucie Bačáková, CSc.
- Czech Technical University in Praha, Faculty of Mechanical Engineering, Doc. RNDr. Vladimír Starý, CSc.
- Brno University of Technology, Faculty of Chemistry, Doc. RNDr. Vladimír Čech, PhD.
- University of Jan Evangelista Purkyně in Ústí nad Labem, Faculty of Science, Doc. RNDr. Stanislav Novák, CSc.
- HVM Plasma, spol. s r.o., Praha, Ing. Jiří Vyskočil, CSc.
- University of South Bohemia in České Budějovice, Pedagogical faculty, Prof. RNDr. Petr Špatenka, CSc.
Objective of the solution: The preparation and characterisation, with the assistance of low-pressure plasma, of nanocomposite layers, especially with the plasma polymer matrix, layered nanocomposites, and the layers consisting of nanoparticles. The research of their application possibilities, including potential applications in biology and medicine. There are researched new methods using the low-pressure plasma based on magnetron configurations, a plasma jet , including the methods of creation cluster and nanoparticles beams.

SUB PROGRAMME 2: Nanobiology and nanomedicine

KAN200520701 “Nano-PCR – the ultrasensitive test detecting specific proteins in body fluids”, 01/2007-12/2011, the researcher is RNDr. Petr Dráber, DrSc., Institute of Molecular Genetics of AS CR, Praha, the total costs of CZK 51.2 million, thereof CZK 43.5 million from the state budget. (Year 2008 – 10.240/8.700, 3e)

Co-researchers:
- Charles University in Praha, 3. Faculty of Medicine, MUDr. Aleš Bartoš
- Praha Psychiatric Center, RNDr. Daniela Řípová, CSc.
- Top-Bio, s.r.o., Praha, Marek Dráber, MBA
- VIDIA spol. s.r.o., Vestec-Jesenice u Prahy, Ing. Michaela Poláková
Objective of the solution: The development of a new diagnostic system for the ultrasensitive detection of rare proteins in body liquids with the dynamic resolution of up to 8 levels. The test is based on the bond of the studied protein with a monoclonal antibody (mAb) immobilised, together with thiolated DNA oligonucleotides, on a golden nanoparticle (NP). The consequent steps will study the complex protein-NP caught and isolated on magnetic immunoparticles. The thiolated DNA oligonucleotides become free and serve as the initiation and limiting DNA primers in the quantitative polymer chain reaction (PCR) in real time. The usability of this method will be verified in the detection of cytoskeleton proteins in body liquids of patients with neuropsychiatric diseases and in the detection of cytokinins. The testing of the use of the scale of new mAb with the nano-PCR method makes a part of the project. It is expected that the nano-PCR will be 6 - 8 times more sensitive, when compared with the common ELISA method, and will allow for the development of new ultrasensitive diagnostic methods of new generations.

KAN200520702 “Nanoimmunosensors detecting cytokines”, 01/2007-12/2011, the researcher is Ing. Peter Šebo, CSc., Biotechnology Institute of AS CR , Praha, the total costs of CZK 62.433 million, thereof CZK 53.018 million from the state budget. (Year 2008 – 12.119/10.241, 4b)

Co-researchers:
- Institute of Microbiology of AS CR , Praha, Ing. Radim Osička, PhD.
- National Institute of Public Health, Praha, MUDr. Marta Havelková, CSc.
- University of Jan Evangelista Purkyně in Ústí nad Labem, Faculty of Science, Mgr. Jan Malý, PhD.
- VIDIA spol. s.r.o., Vestec-Jesenice u Prahy, RNDr. Luděk Lepša, PhD.
- Proteix s.r.o., Jesenice u Prahy, Ing. Jiří Špička
- BVT Technologies, a.s., Brno, RNDr. Jan Krejčí, PhD.
Objective of the solution: The development of the integrated basic research of physical principles and nanotechnological processes allowing the preparation of fast reacting, sensitive, specific, and robust nanoimmunosensors in the Czech Republic for the detection of biological ligands, especially cytokines. The four academic groups have joined with three research-oriented companies for the establishment of a research consortium. It will closely co-operate in the research of relations between the structure and functions of recombinant bond proteins, the mechanisms of their immobilisation on colloid nanoparticles and on nanostructured surfaces, the principles of an effective preparation of optimised nanoelectrode surfaces, and their integration in biosensors. The dynamic characteristics and the selectivity of proposed immunochromatographic and electrochemical sensors will be verified on the model detection of the interferon gamma in defined solutions and in real blood samples of patients suspected of tuberculosis.

KAN200520703 “The use of ultrasound in nanomedicine”, 01/2007-12/2011, the researcher is Doc. Ing. Jiří Neužil, CSc., Biotechnology Institute of AS CR , Praha, the total costs of CZK 92.823 million, thereof CZK 74.123 million from the state budget. (Year 2008 – 16.550/12.800, 3g)

Co-researchers:
- Institute of Physiology of AS CR, Praha, Doc. RNDr. František Kolář, CSc.
- Institute of Organic Chemistry and Biochemistry of AS CR, Praha, RNDr. Miroslav Ledvina, CSc.
- University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Doc. MVDr. Michal Vlašín, PhD.
- Veterinary Research Institute, RNDr. Jaroslav Turánek, CSc.
- Apronex s.r.o., Jesenice u Prahy, Ing. Jiří Špička
- CPN spol. s r. o., Dolní Dobrouč, RNDr. Vladimír Velebný, CSc.
- Top-Bio, s.r.o., Praha, Marek Dráber, MBA
- KRD-obchodní společnost s.r.o., Praha, MUDr. Zdeněk Kleibl, PhD.
Objective of the solution: The development and application of a technology in the area of the so-called nanomedicine, with the assistance of the newest knowledge gained in the field of physical chemistry and biology, which could be used for the very efficient diagnostics and treatment of main diseases occurring in industrialised countries, including the Czech Republic - the neoplastic and cardiovascular diseases. The subject of the programme project relates to the development and application of a modern carrier based on microbubbles - the small particles the surface of which will be created mainly by lipid components, while the inner part is filled with heavy gas. These microbubbles will be modified in such a way that they connect with the targeted tissues, where they will be detected and destroyed by the ultrasound. These so-called “nanoshrapnels” will introduce biologically active substances into the targeted cells and will assist in both diagnostics and treatment. This approach is highly modern and sophisticated and it follows the newest trends in biomedicine - the molecular in vivo targeting. Results of this project will be utilised in future in diagnostics and patients’ treatment.

KAN200520704 “New nanoparticles for the ultrastructural diagnostics”, 01/2007-12/2011, the researcher is Doc. RNDr. Pavel Hozák, DrSc., Institute of Molecular Genetics of AS CR, Praha, the total costs of CZK 88.595 million, thereof CZK 73.525 million from the state budget. (Year 2008 – 17.699/16.499, 3g)

Co-researchers:
- Institute of Macromolecular Chemistry of AS CR, Praha, RNDr. Miroslav Šlouf, PhD.
- Biology Centre of AS CR, Ing. Jana Nebesářová, CSc.
- SEVAPHARMA a.s., Praha, RNDr. Marek Moša, PhD.
- CENTRAL EUROPEAN BIOSYSTEMS s.r.o., Praha, MUDr. Zdeněk Kleibl, PhD.
Objective of the solution: The project should allow for the first time in history of the ultrastructural cytochemistry the sensitive marking of at least four antigens at the same time. It has got the three following main goals: 1) The development of a set of nanoparticles, of the size 5 - 15 nm, of varied shapes or with a component composition, suitable for the ultrastructural cytochemistry. The resulting set will have at least four different stable nanoparticles for the simultaneous detection in electron microscopes. 2) The preparation of stable detection set of nanoparticles conjugated with antibodies for the multiple ultrastructural marking in biomedicine and the in detail characterising of their properties for TEM and SEM. The resulting detection set will be transferred for the commercial completion and dissemination in the scientific community. 3) The development of a diagnostic tool and of a standardised procedure for the ultrastructural characterising of the spectrum of antigens of viral vaccines/fractions of a vaccine against mumps. The result will improve the vaccine quality and the controls of the presence of necessary immune antigens. It should be commercially utilised.

KAN200670701 “Surface plasmon resonance biosensors and protein chips for the medical diagnostics”, 01/2007-12/2011, the researcher is Ing. Jiří Homola, CSc., Institute of Photonics and Electronics of AS CR, Praha, the total costs of CZK 63.555 million, thereof CZK 55.688 million from the state budget. (Year 2008 – 10.828/9.084, 4a)

Co-researchers:
- Institute of Macromolecular Chemistry of AS CR, Praha, RNDr. Eduard Brynda, CSc.
- Institute of Hematology and Blood Transfusion, Praha, Prof. Ing. Jan Evangelista Dyr, DrSc.
- VIDIA spol. s.r.o., Vestec-Jesenice u Prahy, MUDr. Pavel Jinoch
Objective of the solution: The achievement of a significant progress in the research of photonic nanostructures and biofunctions that should allow for the development of a new generation of optic surface plasmon resonance biosensors detecting molecular substances in nanomedicine. The research of the photonic nanostructures is focussed mostly on the metal-dielectric nanostructures with managed or localised surface plasmons which are usable in optical sensors. The research in the area of biological nanostructures focuses on sets of biological and synthetic macromolecules with the managed composition and architecture. An important part of the proposed project relates to the development of new biosensor types with potential applications in medical diagnostics, specifically the multichannel biosensors and multifunctional protein chips for new diagnostic methods for the myelodysplasia syndrome, biosensors for the diagnostics of herpes infections, and the detection of biomarkers of human health defects by polycyclic aromatic hydrocarbons and endocrine disruption agents.

SUB PROGRAMME 3: Nano-macro interface

KAN300100702 “Creation of nanostructures by X-ray lasers”, 01-2007-12/2011, the researcher is Ing. Bedřich Rus, Dr., Institute of Physics of AS CR, Praha, the total costs of CZK 24.345 million, thereof CZK 21.910 million from the state budget. (Year 2008 – 3.111/2.581, 1d)

Co-researchers:
- Institute of Plasma Physics of AS CR, Praha, RNDr. Karel Koláček, CSc.
- Institute of Scientific Instruments of AS CR, Brno, Ing. Jaroslav Sobota, CSc.
- Czech Technical University in Praha, Faculty of Biomedical Engineering, Dr. Ing. Jaroslav Kuba, PhD.
- Reflex s.r.o., Praha, Doc. Ing. Ladislav Pína, DrSc.
Objective of the solution: The utilisation of the state of art high repetition sources of the coherent radiation in the field of the soft X-ray spectrum (10 - 50 nm) for the creation and monitoring of nanometric structures on surfaces of solid substances. It is qualitatively a new research direction focussing on the study of interactions of the highly intensive soft X-ray radiation with a mass which cannot be done with the conventional X-ray/XUV sources. In addition to the pilot study of fundamental physical solid phase ablation processes by the soft X-ray radiation, the project will research and optimise methods of the managed generation of nanostructures, especially in the mode of the ablation monopulse microlithography. This basic plan relates (a) to the implementation and development of highly repetitive sources of the coherent X-ray/XUV radiation on the basis of a capillare discharge and the Ti:sapphire pumping laser, (b) to the development of an advanced X-ray focus optics for the XUV/X-ray beams, and (c) to the development of the XUV/X-ray interferrometry and holography for the diagnostics of surfaces with the nanometric resolution.

KAN301370701 “Nanostructured macroscopic systems – preparation technology and characterising”, 01/2007-12/2011, the researcher is Prof. RNDr. Miroslav Hrabovský, DrSc., Palacky University Olomouc, Faculty of Science, the total costs of CZK 79.858 million, thereof CZK 70.929 million from the state budget. (Year 2008 – 21.071/19.322, 1d)

Co-researchers:
- Institute of Physics of AS CR, Praha, Ing. Ivan Gregora, CSc.
- PIEZOCERAM, s.r.o., Hradec Králové, Ing. Miroslav Boudyš, CSc.
Objective of the solution: The preparation of a complex approach to the technology, diagnostics, optimising, and characterising of modern structured materials for a wide spectrum of applications. The studied materials include thin-layered structures, gradient oxide systems, electroceramic and other technically important materials prepared by the original plasma-chemical methods with the special focus on the nanometric structures. Applications and the work out of modern integrated methods with the high space resolution for the nanometric mapping of surfaces and the complex characterising of samples.

KAN311610701 “Nanometrology using methods of the scanning probe microscopy”, 01/2007-12/2011, the researcher is Mgr. Petr Klapetek, Ph.D., Czech Metrology Institute, Brno, the total costs of CZK 21.151 million, thereof CZK 18.793 million from the state budget. (Year 2008 – 2.993/2.693, 7e)

Co-researchers:
- Institute of Scientific Instruments of AS CR, Brno, Ing. Dr. Josef Lazar, Dr.
- Masaryk University, Faculty of Science, Brno, RNDr. Vilma Buršíková, PhD.
Objective of the solution: The development of methods for the scanning probe microscopy with the focus on the following areas:
1) The development of methods for the precise interferometric measuring of small lengths,
2) The direct connection of the length and shape nanostructure measuring with the state length standards,
3) The quantitative measuring of mechanical properties of nanostructures in combination with the microindentation, nanoindentation, and the scanning probe microscopy,
4) The development of theoretical models of point and surface interaction in the area of scanning probe microscopy and nanoindentation. The development of these methods will create a unique workplace dealing with the quantitative probe microscopy.

SUB PROGRAMME 4: New phenomena and materials for nanoelectronics

KAN400100701 “Functional hybrid semiconductor and metal nanosystems with organic substances (FUNS)”, 01/2007-12/2011, the researcher is RNDr. Bohuslav Rezek, PhD., Institute of Physics of AS CR, Praha, the total costs of CZK 96.021 million, thereof CZK 90.714 million from the state budget. (Year 2008 – 29.351/28.104, 6c)

Co-researchers:
- Charles University in Praha, 1. Faculty of Medicine, Ing. Stanislav Kmoch, CSc.
- Charles University in Praha, Faculty of Mathematics and Physics, Prof. RNDr. Petr Malý, DrSc.
- Brno University of Technology, Faculty of Mechanical Engineering, Prof. RNDr. Tomáš Šikola, CSc.
- Optaglio s.r.o., Řež, Ing. Libor Kotačka, PhD.
Objective of the solution: The connection of nanostructural components into functional units - nanosystems. The objective of this project is the creation of nanostructures based on thin layers of semiconductors (mainly silicon, diamond, and metal oxides), on metals and organic substances (e.g. organic dyes or DNA molecules), their connection into hybrid nanosystems with controls of growth, orientation and the placement with the assistance of physical-chemical parameters. Their functioning will be consequently characterised from the targeted applications points of view, e.g. as nanosensors, nanoelectronics, optoelectronics, or forensic devices. This experimental approach is supported by the theoretical studies and the computer assisted modelling of properties of the nanointerfaces between organic and inorganic materials. It is expected that the project results will contribute to the faster utilisation of nanotechnologies in practice and to the revelation of new phenomena at the levels of atoms and molecules.

KAN400480701 “Nanostructures based on carbon and polymers for the use in bioelectronics and in medicine”, 01/2007-12/2011, the researcher is Mgr. Jiří Vacík, CSc., Nuclear Physics Institute of AS CR, Řež, the total costs of CZK 47.106 million, thereof CZK 44.681 million from the state budget. (Year 2008 – 7.874/7.387, 2e)

Co-researchers:
- Institute of Physics of AS CR, Praha, Ing. Bc. František Fendrych, PhD.
- Institute of Inorganic Chemistry AS CR, Řež, Ing. Zbyněk Černý, CSc.
- Institute of Chemical Technology Praha, Prof. Ing. Václav Švorčík, DrSc.
- Institute of Physiology of AS CR, Department of growth and differentiation of cell populations, Praha, MUDr. Lucie Bačáková, CSc.
Objective of the solution: The preparation and characterising of perspective nanostructured materials (especially based on allotropes of carbon and on synthetic polymers) presenting important biological or other (electric, optic, etc.) properties which could be utilised in interactions with biological systems. The prepared composite materials (created on the basis of fullerenes and metals, carbon and polymers, modified nanocrystalline diamonds, multifunctional carbons, etched ion footprints, or occurring by ion implantation, or ion radiation) will be researched from the point of view of the biocompatibility, cell adhesion and growth, or other bioapplications. Another project objective is the preparation and demonstration of an active hybrid system based on the connection of a cell (or a biomolecule) with a microelectronic part through the interface created with a thin layer of a modified nanocrystalline diamond.

KAN400720701 “Hierarchy nanosystems for microelectronics”, 01/2007-12/2011, the researcher is Ing. Olga Šolcová, CSc., Institute of Chemical Process Fundamentals of AS CR, Praha, the total costs of CZK 50.0 million, thereof CZK 47.5 million from the state budget. (Year 2008 – 9.684/9.184, 2a)

Co-researchers:
- Institute of Physics of AS CR, Praha, Mgr. Zdeněk Hubička, Dr.
- Institute of Microbiology of AS CR , Praha, RNDr. Tomáš Cajthaml, PhD.
- J. Heyrovsky Institute of Physical Chemistry of AS CR, Praha, Ing. Pavel Hrabánek, Dr.
- Institute of Macromolecular Chemistry of AS CR, Praha, Prof. RNDr. Stanislav Nešpůrek, DrSc.
- Charles University in Praha, Faculty of Mathematics and Physics, Doc. RNDr. Radomír Kužel, CSc.
- Institute of Chemical Technology Praha, Faculty of Chemical Technology, Doc. Ing. Petr Klusoň, Dr.
- Výzkumný ústav organických syntéz, a.s., Ústí nad Labem, Ing. Jan Rakušan, CSc.
- University of Jan Evangelista Purkyně in Ústí nad Labem, Faculty of Science, Doc. RNDr. Jaroslav Pavlík, CSc.
Objective of the solution: The creation of complex structured systems with the precisely defined final function usable in microelectronics. The individual parts are made up of small arranged particles ensuring partial functions necessary for the functionality of the whole system. These complex structures should be directly suitable as parts of special sensors, photoelectrochemical energy sources, microelectrodes used in analytical instruments, etc. From the general point of view, the main project objective is the collection of a satisfactory number of high quality experimental data which could be used for the design and completion of practical nanotechnologies. The project focuses on the study of the preparation of hierarchy nanostructures, including the structural and functional characterising and prediction of their properties with the assistance of mathematical modelling.

Review of the public tender 2nd round results:


Sub programme 1 Sub programme 2 Sub programme 3 Sub programme 4 TOTAL
Number in the tender submitted proposals 5 7 4 4 20
Number of projects accepted within the programme 3 5 3 3 14
Success rate (in %) 60 71.4 75 75 70
Recognised costs of accepted projects within the research period (in thousand CZK) 111 406 360 519 125 243 193 127 790 295
Target-oriented support of accepted projects within the research period (in thousand CZK) 88 756 299 861 111 632 182 895 683 144
Average share of the target-oriented support in recognised costs (in %) 79.7 83.2 89.1 94.7 86.4


List of projects accepted for solution within the 3rd round of the public tender There have been the following projects accepted within the 3rd round of the public tender for solution in the period from 1 January 2008 to December 2012:

SUB PROGRAMME 1: Nanoparticles, nanofibres and nanocomposite materials

KAN115600801 “New preparation and use technologies related to nanoparticles based on iron oxides for the environmental, industrial and medical applications”, 01/2008 – 12/2012, the head researcher is Doc. RNDr. Radek Zbořil, PhD., Palacky University Olomouc, Faculty of Science, the total costs of CZK 73.463 million, thereof CZK 58.757 million from the state budget. (Year 2008 – 11.155/8.911, 1a)

Co-researchers:
- H+A Eco Cz s.r.o., Olomouc, Ing. Oleg Lysytchuk, CSc.
- MEDIHOPE s.r.o., Prostějov – Krasice, prim. MUDr. Pavel Novák
Objective of the solution: The project focuses on four key scientific fields mutually interconnected through nanoparticles of iron oxides with the following objectives:
1) The development of advanced iron oxides based catalysts with an extraordinary catalytic effectiveness in the hydrogen peroxide disintegration and other environmentally important processes of the heterogeneous catalysis;
2) The production of new functioning magnetic nanoparticles with the “core-shell” structure, including magnetozomes produced by bacteria applied during the magnetic resonance imaging for the targeted transport of medicine, and other bioapplications;
3) The managed syntheses of Fe-FeO and Fe-Fe3O4 nanocomposites; the semi-operational manufacture and testing in reductive water treatment technologies and in the area of magnetorheological fluid liquids; 4) The use of nanocrystalline hydrated iron oxides (ferrihydrites) as precursors for the synthesis of ferrates by the reaction in the solid phase with the goal of increasing the reaction yield and the technology implementation at large; the testing in the oxidative water treatment technologies.

SUB PROGRAMME 2: Nanobiology and nanomedicine

KAN200100801 “Bioactive biocompatible surfaces and new nanostructured composites for applications in medicine and pharmacy”, 01/2008 – 12/2012, the head researcher is Prof. RNDr. Miloš Nesládek, CSc. HDR., Institute of Physics of AS CR, v. v. i., Praha, the total costs of CZK 121.207 million, thereof CZK 98.556 million from the state budget. (Year 2008 – 27.142/23.200, 3d)

Co-researchers:
- Zentiva a.s., Praha, Ing. Jan Šotola, CSc.
- GENERI BIOTECH s.r.o., Hradec Králové, RNDr. Martin Bunček, PhD.
- University of Pardubice, Faculty of Chemical Technology, Mgr. Jan Mistrík, PhD., Dr.
- University of South Bohemia in České Budějovice, Faculty of Science, Mgr. Lukáš Trantírek, PhD.
- Institute of Chemical Technology Praha, Faculty of Chemical Engineering, Prof. RNDr. Vladimír Král, DrSc.
- Charles University in Praha, 3rd Faculty of Medicine, As. MUDr. Viktor Kočka, FESC.
- Institute of Organic Chemistry and Biochemistry of AS CR, v. v. i., RNDr. Miroslav Ledvina, CSc.
- J. Heyrovsky Institute of Physical Chemistry of AS CR, v. v. i., Prof. RNDr. Ladislav Kavan, DrSc.
- Elmarco s.r.o., Liberec, Ing. Lukáš Rubáček, PhD.
Objective of the solution: The preparation and the study of nanostructured materials with bioactive surfaces, as, for example, new medicine carriers, nanofibres and nanocarbon-based materials, i.e. carbon nanotubes, nanodiamonds, and polymers with significant biocompatibility for the use in medicine, pharmacy and diagnostics. The coating of ceramic nanoparticles and nanofibres with polymers or diamond by nucleic methods of self-assembly and the use of uniquely low temperature of diamond growth below 150°C that should allow for the preparation of new nanocomposites with surfaces suitable for the functioning by biomolecules. The medicine carriers will be studied for the immobilisation of macrocyclic compounds, mostly porphyrins and metaloporphyrins, proteins and polysaccharides respectively. The active surfaces will be studied for the transport of DNA, peptides and cytostatic agents with the targeted therapeutic effect and the simultaneous protection against biodegradation. The chemical surface modifications will focus on applications in medicine dosing and on bioactive biocompatible surgery stents.

KAN200380801 “Immunonanotechnology for the diagnostics of substances having the hormonal character”, 01/2008 – 12/2012, the head researcher is Prof. Miroslav Strnad, DrSc., Institute of Experimental Botany of AS CR, v. v. i., the total costs of CZK 35.122 million, thereof CZK 29.797 million from the state budget. (Year 2008 – 6.044/4.588, 3g)

Co-researchers:
- Palacky University Olomouc, Faculty of Science, Doc. RNDr. Radek Zbořil, PhD.
- Veterinary Research Institute, v. v. i., Brno, Dr. Milan Fránek, DrSc.
- OlChemIm, spol. s r.o., Olomouc, RNDr. Luděk Fröhlich
Objective of the solution: The development of new diagnostic “immunonanotechnologies” allowing for the highly sensitive detection (at the level of atoms and smaller) and for the quantification of hormonal substances of the plant or animal origins at the cell, tissue or plant tissue levels. The project will include the preparation of four basic components of the following nanotechnologies:
1) New kinds of antigens inducing the creation of generic poly or monoclonal antibodies;
2) The development of a new generation of immunosorbents based on functioning magnetic nanoparticles and the development and optimising of the micro and nanoimmunoextraction;
3) The development of a new generation of analytical instruments determining substances of the hormonal nature with the assistance of the combined immunoaffinative chromatography and UPLC/MS/MS at the atomic level;
4) The application of immunonanotechnologies on samples of plant tissues, tissues and cells, including the microdissection application. The project should result in more than 20 new licensed products which could be offered to cooperating companies. It is expected that most products will be exported.

KAN200520801 “Targeted expression and transport of bioactive molecules”, 01/2008 – 12/2012, the head researcher is Mgr. David Staněk, PhD., Institute of Molecular Genetics of AS CR, v. v. i., Praha, the total costs of CZK 72.230 million, thereof CZK 59.805 million from the state budget. (Year 2008 – 15.718/13.233, 3b)

Co-researchers:
- Institute of Experimental Medicine of AS CR, v. v. i., Praha, RNDr. Karel Koberna, CSc.
- Institute of Organic Chemistry and Biochemistry of AS CR, v. v. i., Praha, Ing. Ivan Rosenberg, CSc.
- Institute of Applied Biotechnologies a.s., Praha, MUDr. Josef Fišer
The project has got the two basic objectives:
1. The development of nucleotide and oligonucleotide probes freely going through the membrane and the development of other approaches allowing the transport of diagnostically and therapeutically important substances of the nucleoside type, oligonucleotide or DNA constructions to cells. In addition, it will focus on the development of probes which allow visualisation at the light or electron microscope level without the need of specific antibodies’ use.
2. The creation and testing of a promoter system expressing and verifying the molecular tool - bipartite proteins consisting of two different sub units which, thanks to their mutual interaction (joining) would create a functional molecule. This molecule, if it is able of, for example, fluorescence or a colour reaction, could serve as a molecular sensor. If it is able to destroy a cell, it could be used for the liquidation of ill cells.

KAN200520804 “Biocompatible nanofibrous constructions creating new medicinal forms for the application of biologically and pharmaceutically active substances”, 01/2008 – 12/2012, the head researcher is Doc. RNDr. Vladimír Holáň, DrSc., Institute of Molecular Genetics of AS CR, v. v. i., Praha, the total costs of CZK 48.497 million, thereof CZK 40.124 million from the state budget. (Year 2008 – 8.054/6.808, 3c)

Co-researchers:
- Institute of Experimental Medicine of AS CR, v. v. i., Praha, Prof. MUDr. Eva Syková, DrSc.
- Institute of Macromolecular Chemistry of AS CR, v. v. i., Praha, Ing. Jiří Michálek, CSc.
- Elmarco s.r.o., Liberec, Ing. Marcela Munzarová
Objective of the solution: The research in the area of polymer nanofibre carrier use for the creation of new medicine forms serving for targeted and managed application of pharmacologically and biologically active substances, especially in the area of immunopharmacy. The research will deal with the utilisation possibilities of adsorption and absorption of biologically active substances on nanofibre carriers, but also with the utilisation of nanofibre double layers for the encapsulating of cell cultures releasing immunologically active substances. The biocompatibility and functionality of these constructions will be verified in vitro in tissue cultures and they will be tested on experimental animal models. The final objective is the design and manufacture of completely new medicine forms based on nanofibre technologies widely usable for medical purposes in different areas of medicine.

KAN208130801 “New constructions and use of nanobiosensors and nanosensors in medicine (NANOSEMED)”, 01/2008 – 12/2012, the head researcher is Ing. Jaromír Hubálek, PhD., Brno University of Technology, Faculty of Electrical Engineering and Communication, the total costs of CZK 32.919 million, thereof CZK 27.976 million from the state budget. (Year 2008 – 9.051/6.939, 6c)

Co-researchers:
- Mendel University of Agriculture and Forestry in Brno, Faculty of Agronomy, Doc. Ing. René Kizek, PhD.
- RADANAL s.r.o., Pardubice, Doc. Ing. Aleš Horna, CSc.
Objective of the solution: The creation of a new and original construction of mono or heterogeneous nanosystems, as nanobiosensors and nanosensors suitable for medicine. The progress of medicinal technologies pushes into the front the on-line monitoring of not only physiological parameters of an individual, but also the treatment effect. It is based on the monitoring of the level of glucose, cytostatic agents, and other medicine, or on the simple and fast analysis of the biologically important proteins (p53, p21, metalothionein, glutathion, rb protein, etc.) and the sequences of nucleic acids (the gene for the cystic fibrosis, etc.). The nanosensors and nanobiosensors using materials with unique physical-chemical properties could initiate important progress in the area of detection of biologically and clinically important compounds. The attention will be also paid to magnetic materials suitable for the separation of these compounds. The processes will allow the simple and selective detection and separation of looked for biomolecules and compounds.

SUB PROGRAMME 3: Nano-macro interface

KAN300100801 “Multifunctional metallic bulk materials with nanocrystalline and ultrafine grain structures”, 01/2008 – 12/2012, the head researcher is Prof. Ing. Pavel Lejček, DrSc., Institute of Physics of AS CR, v. v. i., Praha, the total costs of CZK 71.700 million, thereof CZK 64.529 million from the state budget. (Year 2008 – 16.892/15.103, 1e)

Co-researchers:
- Charles University in Praha, Faculty of Mathematics and Physics, RNDr. Ivan Procházka, CSc.
- Institute of Chemical Technology Praha, Faculty of Chemical Technology, Doc. Dr. Ing. Dalibor Vojtěch
- VUK-Kovohutě, s.r.o., Panenské Břežany, Ing. Miloš Choura
Metallic bulk materials with extremely small grain sizes and phases present offer fundamental improvements of their functional and structural properties and thus also significant spreading of their application potential in the transport industry, in medical implants, for the energy storage, and in the mechanical engineering. The project focuses on the preparation of ultrafine and nanocrystalline metallic bulk materials of defined structures and with perspective application properties. The top methods of material characterising should allow for the high quality feedback for the continuous improvement of their properties. The goal is to develop techniques based on severe plastic deformation and rapid cooling with subsequent consolidation and to the 3D diagnostic methodology for nanostructures with the assistance of PAS and 3D grain boundaries topology with FESEM+FIB+EBSD.

KAN300100802 “Nanocomposite, ceramic and thin layer scintillators”, 01/2008 – 12/2012, the head researcher is Ing. Martin Nikl, CSc., Institute of Physics of AS CR, v. v. i., Praha, the total costs of CZK 42.536 million, thereof CZK 37.784 million from the state budget. (Year 2008 – 12.116/11.000, 2c)

Co-researchers:
- Institute of Inorganic Chemistry AS CR, v. v. i., Husinec, Ing. Ivo Jakubec, CSc.
- Charles University in Praha, Faculty of Science, RNDr. Daniel Nižňanský, PhD.
- Charles University in Praha, Faculty of Mathematics and Physics, Doc. RNDr. Miroslav Kučera, CSc.
- Czech Technical University in Praha, Faculty of Nuclear and Physical Engineering, Prof. Ing. Viliam Múčka, DrSc.
- Crytur, spol. s r.o., Turnov, Dr. Jindřich Houžvička
Objective of the project: The development of technologies preparing perspective scintillation materials in the forms of nanopowders, nanocomposites, optical ceramics, and thin layers. There will be their morphologic, optical, luminescence, and scintillation properties studied.


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