Nanotechnologie esk verze
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Program �SUPPORT OF TARGETED RESEARCH PROJECTS� (1Q)
Vydno dne 23. 10. 2008 (1850 peten)

Projects solved in the area of nanotechnologies


1QS100100553 �New hybrid magnetic nanocomposite materials for selected applications in medicine, for the magnetic resonance imaging and the magnetic hyperthermia�, 7/2005-12/2008, the head researcher is Doc. Ing. Emil Pollert, DrSc., Institute of Physics of AS CR, v.v.i., Praha, the total costs of CZK 3.990 million, thereof CZK 3.990 million from the state budget. (Year 2008 � 1.131/1.131, 2d)

Co-researcher:
- Institute of Macromolecular Chemistry of AS CR, v.v.i., Praha, Ing. Daniel Hor�k, PhD.

Objective of the solution: The research of new magnetic nanoparticles for applications in medicine. The project covers the synthesis of magnetic particles based on mixed magnetic oxides, ferromagnetic hexagonal ferrits and ferromagnetic manganites of defined properties, their stabilisation and consequent preparation of composite nanoparticles in the use of biocompatible molecules and polymers. The particle surface is suitably modified with the goal to immobilise, for example, the cancer medicine. The treatment of the resulting composites� properties focuses mostly on their consequent utilisation in the treatment of tumorous diseases by the magnetic hyperthermia or as contrast agents in the magnetic resonance imaging methods (MRI).

1QS201710508 �Impedimetric chemical microsensors with the nanomachined surfaces of electrodes�, 1/2005-12/2009, the head researcher is Ing. Jarom�r Hub�lek, PhD., Brno University of Technology, Faculty of Electrical Engineering and Communication, the total costs of CZK 11.387 million, thereof CZK 9.671 million from the state budget. (Year 2008 � 2.274/1.930, 4a)

Objective of the solution: The project is considered as the targeted and applied research. It should result in new technological processes in the area of nanotechnologies which should be adjusted for the construction of new microsensors used for chemical analyses. There should be processes designed which allow for the combination of existing thick layer and thin layer technologies with the new nanotechnologies. The goal will be the finding of optimal diagnostic methods for the utilisation in the analysis of created nanostructures. The project is focussed mainly on the characterising of impedance characteristics of new microsensors and on their dependency on the technology and measured values. The project is based on the strong research and development background and focuses on industrial applications. In addition to processes, there will be also electronic sensor parts developed for the implementation in the form of microchips. The project should contribute intelligent SMART sensors to the chemical analyses requiring the high preciseness and stability.

1QS401250509 �Ceramic materials of the hierarchy porous structure for the membrane separation technologies�, 1/2005-2/2008, the head researcher is Doc. Ing. Bohumil Bernauer, CSc., Institute of Chemical Technology Praha, Faculty of Chemical Technology, the total costs of CZK 8.063 million, thereof CZK 8.063 million from the state budget. (Year 2008 � 2.003/2.003, 5a)

Co-researchers:
- University of Pardubice, Faculty of Chemical Technology, Prof. Ing. Petr Mikul�ek, CSc.
- J. Heyrovsky Institute of Physical Chemistry of AS CR, v.v.i., Praha, RNDr. Milan Ko�i��k, CSc.
- Institute of Chemical Process Fundamentals of AS CR, v.v.i., Praha, Ing. Petr Uchytil, CSc.
- Ing. Vladim�r Kotek, Hradec Kr�lov�

Objective of the solution: Membrane technologies have become important alternatives to classical technologies. The all ceramic membranes are important in high temperature processes. The project has been inspired by the need of reduced costs of preparation of micro and nanofiltration membranes of the hierarchy porous structure. The reduction of the manufacturing intensity related to hierarchy membrane structures requires a lower number of transition layers in nanofiltration membranes. The nanofiltration layers will be done on the basis of zeolite silica-1, NaA, NaY, and DD3R. The main project�s goals are (i) the gaining of laboratory preparation processes for standard quality ceramic carriers with a minimal number of transition layers and (ii) the gaining of preparation processes for standard quality nanofiltration layers on these layers. The authors have got some ideas how to reduce the number of transitional layers and one of them relates to the use of crystalline eyes on the carrier surfaces. The main results will be materials for the consequent industrial research and development.

1QS500110564 �New hybrid bio-artificial vascular substitutes by the tissue engineering methods�, 7/2005-12/2009, the researcher is MUDr. Lucie Ba��kov�, CSc., Institute of Physiology of AS CR, Praha, the total costs of CZK 8.857 million, thereof CZK 8.857 million from the state budget. (Year 2008 � 2.034/2.034, 3c)

Co-researcher:
- Institute of Macromolecular Chemistry of AS CR, v.v.i., Praha, RNDr. Franti�ek Ryp��ek, CSc.

Objectives of the solution: The clinically used vein replacements, manufactured by the knitting technology from PET fibres in VUP a.s. in Brno, are improved by the application of new biomaterials based on copolymers, polyesters, and polyethylenoxide. These modifications limit the adsorption of proteins, the adhesion and activation of thrombocytes and immune cells, and the permeability of the replacement wall. There were biomaterials of specific functions, adhesive proteins or peptide sequences applied in the next step and they selectively supported the adhesion of endothelial cells with the aim to stimulate the creation of a continuous endothelial bed on the luminal surface of the vein replacement. In the final stage, the biomaterials with bound adhesive nanostructures, ensuring the selective interactions with cells, utilised for the preparation of complete vein replacements, new hybrid tissues made of organised cell structure of endothelial and smooth muscle cells on the carrying skeleton of the polymer biomaterial. The in vitro tissue cultivation in a dynamic reactor is developed during preparations of vein replacements of a new generation.

1QS600220501 �Application workplace for the low-voltage electron microscopy used for biological preparations�, 1/2005-12/2009, the researcher is Ing. Jana Nebes��ov�, CSc., Biology Centre of AS CR, v.v.i., Institute of Parasitology, �esk� Bud�jovice, the total costs of CZK 3.194 million, thereof CZK 3.194 million from the state budget. (Year 2008 � 0.553/0.553, 7a)

Objectives of the solution: The low-voltage electron microscope LV EM is a new microscope kind specially designed for the observation of samples consisting of elements having low atomic numbers, e.g. biological objects. It uses primary electrons speeded up by the voltage of 5 kV. These relatively slow electrons can penetrate samples of the thickness of only 20 nm, but with the very high contrast amplification, which allows for the omission of contrasting procedures during preparate preparations.
This project creates an application workplace for the low-voltage electron microscopy focussed on resolving the following problems:
1) The preparates� preparations for LV EM and the interpretation of gained results,
2) The finding of suitable applications in biology and medicine, and
3) The microscope promotion among experts.


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