Nanotechnologie esk verze
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Program �Healthy and Quality Life� (2B)
Vydno dne 20. 11. 2008 (1843 peten)

Projects solved in the area of nanotechnologies

2B06056 �Diagnostics of by polyaromatic compounds damaged DNA with the use of nanotechnological and bioanalytical methods for the early detection of cancers�, 7/2006-6/2010, the head researcher is Mgr. Jan P�ibyl, PhD., Masaryk University in Brno, Faculty of Science, the total costs of CZK 9.998 million, thereof CZK 8.998 million from the state budget.
(Year 2008 � 1.348/1.216, 3g, the nanotechnology research share makes up 60% of the allocated sum.)

Co-researcher:
- EXBIO Praha, a.s., Ing. Miloslav Such�nek, PhD.
Objective of the project: The indirect carcinogens like, for example, benzo pyrene, cause malignancy by the chemical modification of nucleic acids and related substances and by preventing the natural functioning of human cells. The project wishes to contribute to the area of revealing this process mechanism by the precise localisation of damages with the assistance of nanotechnological imagining techniques. For this purpose, there will be antibodies prepared which would be specific, according to the damaged place, the bound molecule respectively. These antibodies will be then utilised for the development of methods allowing a simple, fast, but precise identification of the mentioned damages. Methods of the heterogenous immunoanalysis (ELISA) or biosensors with a transducer based on a surface plasmon look like the most perspective in this area. The localisation of damages on DNA is further studied with the assistance of the AFM technique utilising the nanoparticle marked antibodies as tools making the damaged areas visible.

2B06104 �Photosensibilisers in dental medicine�, 7/2006-12/2010, the researcher is Ing. Marie Kar�skov�, V�zkumn� �stav organick�ch synt�z, a.s., Pardubice, the total costs of CZK 30.500 million, thereof CZK 27.454 million from the state budget.
(Year 2008 � 5.649/5.084, 6d)

Co-researcher:
- Charles University in Praha, Doc. MUDr. Radovan Slez�k, CSc.
Objective of the project: The development of phthalocyanine derivates, which present, thanks to their arrangements, properties of effective photosensibilisers and which are also suitable for the fixation of nanoparticles on selected carriers. The prepared compounds and nanocomposites will be tested from the point of view of creation of the single oxygen after light exposure, but also on their antimicrobial effectiveness. Their retention on targeted tissues and the biocompatibility with human cells will be also studied. There will be an optimal combination of a photosensibiliser and the relevant nanocarrier selected, according to results of the in vitro conducted pre clinical tests, and it will be recommended for consequent clinical tests.

2B06130 �The utilisation of the newly synthetised biomaterials in combination with stem cells in the treatment of diseases affecting human tissues derived from mesoderm: the cartilage, bone, ligaments, and meniscus�, 7/2006-6/2011, the head researcher is Prof. MVDr. Alois Ne�as, PhD., University of Veterinary and Pharmaceutical Sciences Brno, the total costs of CZK 80.499 million, thereof CZK 72.450 million from the state budget.
(Year 2008 � 4.705/4.234, 3d, the nanotechnology research share makes up 30% of the allocated sum.

Co-researchers:
- Masaryk University in Brno, Faculty of Medicine, Prof. MUDr. Petr G�l, PhD.
- Brno University of Technology, Faculty of Chemistry, Prof. RNDr. Josef Jan���, CSc.
- Institute of Animal Physiology and Genetics of AS CR, v.v.i., Lib�chov, Prof. MVDr. Jan Motl�k, DrSc.
- Institute of Experimental Medicine of AS CR, v.v.i., Praha, Prof. MUDr. Eva Sykov�, DrSc.
Objective of the project: The gaining of fundamental information about biological properties of stem cells in combination with newly synthetised polymer biomaterials and nanofibres, both in tissues and in vitro. The main attention will be paid to the preparation of effective methodologies managing the differentiation of stem cells to chondrocytes, osteocytes, and fibrocytes. There will be also testing of their compatibility with the mentioned biomaterials and the populations will be characterised in a complex way. The project will be directed in such a way that the experimental development would result in technologies which should guarantee the secure use of biomaterials into which there would be cells determined for transplantation to bones, joints, tendons, and ligaments of small pigs and rabbits inserted. The biomaterial composites with cells induced for differentiation will be transplanted to the relevant places in the muscle-skeletal system of the optimal animal models (the miniature pig and rabbit) for the purpose of verification of their effectiveness in the treatment of serious diseases of joints and bones. This experimental work is important for the development of secure and effective technologies before the start of clinical studies and before the clinical use of these biomaterials as replacements of the irreversibly damaged cells and human tissues.

2B08062 �Genetic and physiological handling of bacterial degradation agents in aromatic pollutants and their utilisation (AROMAGEN)�, 1/2008-12/2011, the researcher is Ing. Miroslav P�tek, CSc., Institute of Microbiology of AS CR , v.v.i., Praha, the total costs of CZK 29.900 million, thereof CZK 26.900 million from the state budget.
(Year 2008 � 6.375/5.773, 1g)

Co-researchers:
- DEKONTA, a.s., Ing. Petra ���kov�
- MikroChem LKT spol. s r.o., Mgr. Marius Byss
- Technical University in Liberec, Faculty of Mechatronics, Doc. Dr. Ing. Miroslav �ern�k, CSc.
- Institute of Chemical Technology Praha, Prof. RNDr. Vladim�r Jirk�, DrSc.
Objective of the project: The creation of a system of preparation and the utilisation of bacterial degraders of aromatic pollutants with the use of genetic manipulation, nanofibres as the carriers of microbial biofilm and of humic additives and the testing of their biodegradation function in real situations. The first step in the application of biofilms will be the use of nanofibres as a new carrier variant which could positively influence the development and the structural stability of biofilms and thus also the required remedy function. We expect, on the basis of the executed experiments, that these carriers will be suitable especially for applications of biofilms of rhodococci for the remedy of specifically contaminated waste water and for the intensification of classical treatment technologies.


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