Nanotechnologie esk verze
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Program �Basic Research Centres� (LC)
Vydno dne 20. 11. 2008 (2109 peten)

Projects solved in the area of nanotechnologies

LC06007 �Centre of modern optics�, 3/2006-12/2010, the head researcher is Mgr. Jarom�r Fiur�ek, PhD., Palacky University Olomouc, Faculty of Science, the total costs of CZK 52.481 million, thereof CZK 48.278 million from the state budget.
(Year 2008 � 0.876/0.802, 2c, the nanotechnology research share makes up 10% of the allocated sum.)

Co-researcher:
- Institute of Scientific Instruments of AS CR, v.v.i., Brno, doc. RNDr. Pavel Zem�nek, PhD.
Objective of the project: The Centre of Modern Optics (CMO) associates the two important Czech optical workplaces - the Department of optics of the Palacky University Olomouc and the Institute of Scientific Instruments of AS CR in Brno. The Centre focuses on the objective to get these two research teams closer together and to support their complementary experimental and theoretical research activities in priority areas of modern optics like, for example, the utilisation of quantum and classical principles in the design of new methods for optical processing and transfer of information, optical micro handling, and nanometrology. The Centre also allows for extending research activities of the workplaces, when it comes to materials and personnel and gets them closer to the leading European workplaces. It also supports education of new post graduates and young researchers and co-operation with top foreign research teams, and from it resulting better participation in the network of elite European research workplaces.

LC06010 �Centre of biocatalysis and biotransformation�, 3/2006-12/2010, the researcher is Doc. Ing. Vladim�r K�en, DrSc., Institute of Microbiology of AS CR , v.v.i., Praha, the total costs of CZK 61.480 million, thereof CZK 61.373 million from the state budget. (Year 2008 � 11.263/11.263, 5b)

Co-researchers:
- Institute of Systems Biology and Ecology of AS CR, v.v.i., RNDr. R�diger Ettrich, PhD.
- University of South Bohemia in �esk� Bud�jovice, Faculty of Science, Mgr. Ivana Kut� Smetanov�, PhD.
- Masaryk University in Brno, Faculty of Science, Doc. Mgr. Ji�� Damborsk�, PhD.
Objective of the project: The development and optimising of new biocatalysts (dehalogenase, esterase, nitrilase, amidase, glucosidase, and other selected enzymes), the study of mechanisms of biocatalysis and molecular structures of these enzymes, the development and implementation of methods for the study of structures and functions of enzymes, and for their targeted optimising. The works relate to the area of bionanotechnologies and nanocatalysis. The main utilised methodologies are as follows: the screening of new microbial enzymes and the creation of libraries, the methods for the managed evolution, cloning and gene expression, the crystallisation of proteins and the consequent analysis, the molecular modelling, modification and development of new software, the chemoenzymatic synthesis, and the biotransformation verifying practical enzyme applications. The education of undergraduates and post graduates, the organisation of methodology seminaries, workshops, scientific congresses, and the development of international relations, especially the participation in international projects, make also parts of the project.

LC06035 �Centre of biophysical chemistry, bioelectrochemistry and bioanalysis. New tools for genomics, proteomics, and biomedicine�, 3/2006-12/2010, the head researcher is Doc. RNDr. Miroslav Fojta, CSc., Institute of Biophysics of AS CR, v.v.i., Brno, the total costs of CZK 48.494 million, thereof CZK 48.494 million from the state budget.
(Year 2008 � 1.903/1.903, 3e, the nanotechnology research share makes up 20% of the allocated sum.)

Co-researchers:
- Charles University in Praha, Prof. RNDr. Ji�� Barek, CSc.
- Masaryk University in Brno, Faculty of Science, Doc. RNDr. Ji�� Pazourek, PhD.
- University of Pardubice, FCHT, Prof. Ing. Karel Vyt�as, DrSc.
- Masaryk Memorial Cancer Institute in Brno, RNDr. Bo�ivoj Vojt�ek
Objective of the project: It is necessary to prepare simple and cheap methods allowing the analysis of genome details of individuals after the finalising the human genome project. The world science is currently focussing on the electrochemical detection of DNA during this analysis. The DNA electro activity was found by the Institute of Biophysics of AS CR in Brno. This workplace has more than 40-year-long traditions and belongs among leaders in this area. Partner laboratories have recently achieved an important progress in the research of electrochemical DNA sensors and in the analysis of proteins and other substances. The project is based on the achieved results and focuses on the advanced research of properties of biomacromolecules and their interactions with surfaces, especially electrodes, and on the research of intermolecular DNA interactions and proteins important in relation to serious diseases (cancer, Parkinson and Alzheimer diseases). There will be new approaches and methods designed on the basis of electrochemistry, miniaturising, and nanotechnologies for the modern biology and biomedicine of the 21st century.

LC06040 �Structures for nanophotonics and nanoelectronics�, 3/2006-12/2010, the head researcher is Prof. RNDr. Tom� �ikola, CSc., Brno University of Technology, Faculty of Mechanical Engineering, the total costs of CZK 37.151 million, thereof CZK 37.151 million from the state budget.
(Year 2008 � 6.813/6.813, 2a)

Co-researcher:
- Institute of Physics of AS CR, v.v.i., Praha, RNDr. Anton�n Fejfar, CSc.
Objective of the project: The finding or creation of a nanostructure with its possible utilisation in photonic or electronic parts. The research of photonic, electronic and transport properties of nanostructures utilises the combination of top technological methods and processes, e.g. the local anodic oxidation done by the scanning probe microscopes (SPM), the selective growth utilising the managed self-assembly with the prepared methods like the fluorescence optical microscopy, spectroscopy, local conductivity measuring, and the SPM potential. The project utilises complementary knowledge and top technological measuring facilities of both workplaces, which participate in the project solution, but also the direct co-operation with X-ray multilayer mirrors replication technologyX-ray multilayer mirrors replication technologyforeign workplaces. There are at least 10 post graduates from the Technical University and the Institute of Physics participating in the Centre activities.

LC06041 �Preparation, modification and characterising of materials by energy radiation�, 3/2006-12/2010, the researcher is Doc. Ing. Vladim�r Hnatowicz, DrSc., Nuclear Physics Institute of AS CR, v.v.i.. Husinec-�e�, the total costs of CZK 60.415 million, thereof CZK 52.764 million from the state budget.
(Year 2008 � 2.982/2.357, 6b, the nanotechnology research share makes up 40% of the allocated sum.)

Co-researchers:
- Institute of Inorganic Chemistry AS CR, v.v.i., Husinec-�e�, Ing. Jan �ubrt, CSc.
- University of Jan Evangelista Purkyn� in �st� nad Labem, Faculty of Science, Doc. RNDr. Jaroslav Pavl�k, CSc.
- Czech Technical University in Praha, Institute of Technical and Experimental Physics, Ing. Jan Jak�bek, PhD.
- Institute of Chemical Technology Praha, FCHT, Prof. Ing. V�clav �vor��k, DrSc. - Czech Technical University in Praha, Faculty of Electrical Engineering, Prof. Ing. Jan Vobeck�, DrSc.
Objective of the project: The project concentrates the instrument and personnel capacities of the participants for the achievement of higher internationally comparable level of the experimental and theoretical studies: - effects of the energy radiation on the structure and properties of substances and the possibilities of their utilisation for the preparation of new materials and structures having important electric, optic, and biological properties; - the development of preparation methods for nano and micro structured materials potentially applicable in electronics, optoelectronics and medicine; - the development of new methods for the complex material diagnostics, especially the ones which are still not at the disposal in the Czech Republic, including the development of detectors providing the high energy and space resolution.

LC06063 �Fluorescence microscopy in the biological and medical research�, 3/2006-12/2010, the researcher is Doc. Martin Hof, Dr.rer.nat., J. Heyrovsky Institute of Physical Chemistry, Praha, the total costs of CZK 83.684 million, thereof CZK 83.085 million from the state budget.
(Year 2008 � 10.873/10.873, 7a, the nanotechnology research share makes up 70% of the allocated sum.)

Co-researchers:
- Institute of Physiology of AS CR, v.v.i., Praha, RNDr. Lucie Kub�nov�, CSc.
- Institute of Macromolecular Chemistry of AS CR, v.v.i., Praha, Doc. RNDr. Pavel Hoz�k, DrSc.
- Charles University in Praha, Faculty of Science, Doc. RNDr. Zdena Palkov�, CSc.
Objective of the project: The development of new fluorescence microscopy processes for the studies of dynamic processes in living cells and in model systems, which should allow for the gaining of new knowledge from the areas of non viral gene therapy, signal transduction and the regulation of gene expression. The project includes the development of fluorescence techniques having the sensitivity of a single molecule and of methodologies for the data processing, the development of new DNA condensers, the establishment of the role of G proteins in hormonal actions, the development of new ways of the fluorophor marking of protein molecules, the clarification of interactions of proteins participating in the organisation of the cell core, and of the role of transport proteins in plasmatic membrane.

LC510 �Centre of nanotechnologies and materials for nanoelectronics�, 2/2005-12/2009, the head researcher is RNDr. Jan Ko�ka, DrSc., Institute of Physics of AS CR, v.v.i., Praha, the total costs of CZK 89.376 million, thereof CZK 69.469 million from the state budget.
(Year 2008 � 18.473/14.515, 2a)

Co-researchers:
- Charles University in Praha, Faculty of Mathematics and Physics, Doc. RNDr. Jan Valenta, PhD.
- J. Heyrovsky Institute of Physical Chemistry of AS CR, v.v.i., Praha, Prof. RNDr. Ladislav Kavan, CSc.
Objective of the project: The Centre focuses on the nanoelectronics area which should allow for the utilisation of unique quantum phenomena, but which require problem solutions in 3 branches of the basic research: I) The finding of new sources of photons which allow the photon transfer; II) The use of the charge carriers� spin in semiconductor nanostructures for the maintenance and transmission of information; III) The use of new materials instead of the currently dominating crystalline silicon - e.g. diamond or the nanostructures of unique properties (carbon nanotubes). The main objective will be the preparation and selection of the most perspective spintronic materials from the point of view of working temperature and the spin coherence time, which directly determines the surface electronic properties and the surface bioactivation. Then, there will be new biosensors or by the field governed nanotransistors designed, carbon nanotubes and fulleren enclosures will be prepared and their structure, electronic and photochemical properties will be studies. An important objective of the Centre is the creation of the interdisciplinary platform, which is missing in the Czech Republic, interconnecting physics, chemistry, electronics, and biology. The candidates will verify possibilities of the research interconnection in the areas of Si and carbon nanostructures and the integration of optoelectronic and spintronic structures. LC523 �Perspective inorganic materials�, 2/2005-12/2009, the head researcher is Prof. Ing. Miloslav Frumar, DrSc., University of Pardubice, the total costs of CZK 92.254 million, thereof CZK 58.855 million from the state budget.
(Year 2008 � 1.913/1.215, 1a, the nanotechnology research share makes up 10% of the allocated sum.)

Co-researcher:
- Institute of Inorganic Chemistry AS CR, v.v.i., Husinec-�e�, Ing. Jan �ubrt, CSc.
Objective of the project: The basic research of new inorganic materials, organic metalloid and organometallic compounds with the perspective utilisation in electronics, optics, optoelectronics, in the glass industry, in the industry of ceramics, in nanotechnologies, and also as pigments. The attention will be paid to the determination of the structure, chemical composition and physical and chemical properties, especially the chalcogenides which could be practically used in the high-tech technologies. The attention will be also paid to the studies of optically and thermally induced phenomena in new materials. The project�s objective relates also to the increased competitiveness of the basic research, the improved education of post graduates, graduates, and to the better standard of both national and international co-operation by both co-operating organisations.


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