Nanotechnologie esk verze
  BITCOIN
Programme �RESEARCH CENTRES� (1M)
Vydno dne 06. 11. 2008 (2143 peten)

There are 8 out of the total 25 centres of the 1M type focussing on nanotechnologies partly or fully.

Projects solved in the area of nanotechnologies.

1M0505 �Centre of targeted therapeutic drugs�, 1/2005-12/2009, the researcher is Doc. MUDr. Vladim�r Viklick�, CSc., Nuclear Research Institute �e�, a.s., the total costs of CZK 157.173 million, thereof CZK 139.073 million from the state budget. (Year 2008 � 18.972/16.800, 3b, the nanotechnology research share makes up 60% of the allocated sum.)

Co-researchers:
- EXBIO, a.s., Vestec, Ing. Franti�ek �krob
- Institute of Microbiology of AS CR , v.v.i., Praha, Prof. RNDr. Blanka ��hov�, DrSc.
- Institute of Macromolecular Chemistry of AS CR, v.v.i., Praha, Doc, Ing. Karel Ulbrich, DrSc.
- Institute of Experimental Botany of AS CR, v.v.i., RNDr. Karel J. Angelis, CSc.
- Institute of Molecular Genetics of AS CR, v.v.i., Praha, RNDr. Milan F�bry, CSc.
- Charles University in Praha, Faculty of Science, Doc. RNDr. Karel Bezou�ka, CSc.
Objective of the project: The works by the Centre are focussed on molecular biology and bionanotechnologies. There are the following activities conducted: the construction of new hybridoma lines against antigens potentially useful as targets for the tumour treatment; there are preparation technologies worked on which related to recombinant fragments of monoclonal antibodies - bond and multiple bonds; the required proteins for the centre�s needs should be produced in the 3rd year of the project. It is also about: the design of effective purification methods for the produced recombined antibodies; the design of a structure, synthesis and utilisation of three polymer carriage systems for the construction of directed medicine; the design of a structure, preparation and testing of biological effects of ligand dendrimers (saccharide and peptide ones) and their application as immunodiagnostic and immunotherapeutic instruments. The practical outcome should be a multifunctional bioconjugate containing dendrimers. There is the research of biotransformation routes of tumour effective medicine and their effects conducted as well as the development and synthesis of new anti cancer medicine well tolerated by our organism (bioconjugates and directed medicine).

1M0506 �Centre of molecular and cellular immunology�, 1/2005-12/2009, the researcher is Prof. RNDr. V�clav Ho�ej��, CSc., Institute of Molecular Genetics of AS CR, v.v.i., Praha, the total costs of CZK 169.218 million, thereof CZK 149.718 million from the state budget. (Year 2008 � 3.390/3.000, 3g, the nanotechnology research share makes up 10% of the allocated sum.)
Co-researchers:
- EXBIO, a.s., Vestec, Ing. Miloslav Such�nek, PhD. - APRONEX, s.r.o., Jesenice, RNDr. Ladislav And�ra, CSc.
- Institute of Microbiology of AS CR, v.v.i., Praha, Ing. Peter �ebo, CSc.
- Charles University in Praha, Faculty of Science, Mgr. Jan �ern�, Dr.
Objective of the project: The works by the Centre are focussed on molecular biology and bionanotechnologies. The objective is to clarify immunity functions of some signalling immunocyte molecules (adapter proteins PAG, NTAL, LIME, and non receptor phosphatases) and of their functions in some diseases; the identification, cloning and functional characterising of potentially new signalling proteins which participate in activities ensuring the correct starts and regulation of immunity reactions; the implementation of the production of recombinant factors Wnt1 and Wnt3a and their use for the clarification of the role of the Wnt-signalling route, when suppressing apoptis; the characterising of the roles of signalling and immunoregulation molecules (cytokinins, bacterial toxins and other natural and synthetic immunomodulators) in the activation of macrophages and dendritic cells, e.g. in xenotransplantation reactions (transplants of corneas); the construction of series of potentially commercially important:
(a) hybridome lines producing monoclonal antibodies against important and known, but also newly found signalling immunocyte proteins;
(b) relevant recombinant proteins;
(c) proteins marked with fluorophores.

1M0512 �Research centre of powdered nanomaterials�, 1/2005-12/2009, the head researcher is Prof. RNDr. Miroslav Ma�l��, CSc., Palacky University Olomouc, the total costs of CZK 87.318 million, thereof CZK 78.528 million from the state budget. (Year 2008 � 16.210/14.587, 1a)

Co-researchers:
- Textile Testing Institute, s.p., Brno, RNDr. Pavel Mal��k
- Institute of Physics of Materials of AS CR, v.v.i., Brno, Ing. Old�ich Schneeweiss, DrSc.
Objective of the project: The Research Centre focuses on the synthesis of metallic nanoparticles and metal oxides with properties suitable for their practical use as nanopigments, catalysts, and sorption and purification materials. The research activity consists of the three basic steps: the synthesis of powder nanomaterials, their complex physical and chemical characterising, and the practical testing in selected areas of application. The research education of students in graduation and post graduation programmes focuses on the issues of nanoparticles, nanomaterials, and, most of all, on their practical utilisation. Needs of potential users are considered, when topics of dissertation and graduation studies are selected.

1M0538 �Centre of the cell therapy and tissue repair�, 1/2005-12/2009, the researcher is Prof. MUDr. Eva Sykov�, DrSc., Charles University in Praha, 2nd Faculty of Medicine, the total costs of CZK 167.459 million, thereof CZK 150.300 million from the state budget. (Year 2008 � 10.090/9.044, 3c, the nanotechnology research share makes up 30% of the allocated sum.)

Co-researchers:
- Institute of Clinical and Experimental Medicine, Praha, Ing. Milan H�jek, DrSc.

- Institute of Hematology and Blood Transfusion, Praha, MUDr. Petr Kobylka, CSc.
- Institute of Macromolecular Chemistry of AS CR, v.v.i., Praha, RNDr. Franti�ek Ryp��ek, CSc.
- Institute of Animal Physiology and Genetics of AS CR, v.v.i., Prof. RVDr. Jan Motl�k, DrSc.
- Institute of Experimental Medicine of AS CR, v.v.i., Praha, Doc. Alexandr Chv�tal, DrSc.
Objective of the project: The cell therapy is an alternative in treatments of degenerative and civilisation diseases, including the nervous diseases. The goal of the cell therapy is the replacement, repair, or improvement of damaged tissue functions, especially with the assistance of stem cells. This is achieved by implanting isolated and well-characterised cells into the target organ, at the satisfactory number and quality, which should start the function renewal. The research of biocompatible bio gels and their abilities to support the renewal and replacement of damaged tissues, and increasing the chances of regeneration, make parts of this project. The project�s objective is the conducting of clinical tests and the use of verified processes in the clinical practice. One of the project�s activities is the development of nanoparticles suitable for the marking of different kinds of stem cells. Other activities relate to the preparation of polymer nanofibres and their use in preparations of scaffolds.

1M0554 �Advanced remedial technologies and processes�, 1/2005-12/2009, the researcher is Doc. Ing. Dr. Ji�� Mary�ka, CSc., Technical University in Liberec, Faculty of Mechatronics, the total costs of CZK 169.789 million, thereof CZK 151.807 million from the state budget. (Year 2008 � 3.422/3.072, 1a, the nanotechnology research share makes up 10% of the allocated sum.

Co-researchers:
- Czech Geological Survey, RNDr. Martin Nov�k, PhD.
- University of Jan Evangelista Purkyn� in �st� nad Labem, Doc. Ing. Pavel Jano�, CSc.
- AQUATEST, a.s., Praha, Doc. Ing. Miroslav �ern�k, CSc.
- V�zkumn� �stav anorganick� chemie, a.s., �st� nad Labem, Ing. Josef Kozler, CSc.
- Institute of Information of AS CR, v.v.i., Praha, Ing. Julius �tuller
Objective of the project: The concentrated research conducted in the area of new progressive processes and technologies reacting to the more strict trends occurring in the area of requirements on the quality of underground waters and the mineral environment. The applied research focuses on technological processes and methods of immobilising and in situ removal of contamination also in combination with classical technologies. In parallel with technological and process solutions, the research focuses on the study and development of modern methods of mathematical modelling of geochemical and biochemical processes and systems with the goal of improving predictions of their development in time. An inseparable part of the research plan of the centre is the research of methods evaluating risks for the population in contaminated areas or areas affected by accidents, the issue of reliability and risk analyses related to hazardous operations, and the assessment activities. The utilisation of the zero-valent nanoiron is tested for maintenance works.

1M0577 �Research centre of nanosurface engineering�, 1/2005-12/2009, the head researcher is Ing. Franti�ek Peterka, PhD., ATG, s.r.o., Praha, the total costs of CZK 83.638 million, thereof CZK 78.191 million from the state budget. (Year 2008 � 16.210/14.587, 1d)

Co-researchers:
- Technical University in Liberec, Ing. Ale� Kolouch, PhD.
- Institute of Chemical Technology Praha, Doc. Ing. Josef Kr�sa, Dr.
- J. Heyrovsky Institute of Physical Chemistry of AS CR, v.v.i., Praha, RNDr. Jarom�r Jirkovsk�, CSc.
- Institute of Inorganic Chemistry AS CR, v.v.i., Husinec-�e�, Ing. Jan �ubrt, CSc.
Objective of the project: The complex study of unique photocatalytic properties of nanocrystalline titanium oxide focussed on potential consequent industrial applications in the areas of self-cleaning and hygienic surface treatments, the photocatalytic cleaning and disinfection of the air, water and contaminated soils, organic syntheses and the utilisation of solar energy. The partial research topics are as follows: (i) The synthesis of highly photo active titanium oxide nanoparticles, including doped or mix materials with the spectral sensitivity extended into the visible area; (ii) The preparation of layers based on nanocrystalline titanium oxide from the gaseous phase by the technique of plasma depositing, but also from the solution with the assistance of varied chemical processes, including the advanced methods utilising micelles as templates for the creation of a defined porous structure; (iii) The characterising of nanoparticles and nanocrystalline layers of titanium oxide focussed on the finding of direct relations between material properties and the photo activity; (iv) The development of standard methods testing the self-cleaning abilities and disinfection effects of the photocatalytic surfaces; (v) The construction of different kinds of laboratory photoreactors for the photocatalytic cleaning and disinfection of the gaseous, liquid or solid phases and their testing for the purpose of optimising working conditions; (vi) The study of kinetics and the mechanism of photocatalytic processes deactivating microorganisms and the oxidative mineralisation of organically harmful agents from the point of view of possible creation of dangerous degradation side products; (vii) The use of the photocatalysis for purposes of the organic synthesis.

1M06002 �Optical structures, detection systems and the related technologies for the low-photo number applications�, 3/2006-12/2009, the researcher is Prof. RNDr. Miroslav Hrabovsk�, DrSc., Palacky University Olomouc, Faculty of Science, the total costs of CZK 71.396 million, thereof CZK 62.319 million from the state budget. (Year 2008 � 2.538/2.228, 2c, the nanotechnology research share makes up 20% of the allocated sum.)

Co-researchers:
- Meopta � optika, a.s., P�erov, RNDr. Zden�k Lo���k
- Institute of Physics of AS CR, v.v.i., Praha, RNDr. Ond�ej Haderka, PhD.
Objective of the project: The research of optic structures, detection methods and constructions of detection structures and systems of the weak and ultra weak optic radiation in the visible, UV close and infrared spectral areas, also similar optic structures, and related optic technologies. It is about the detection of extremely weak optic radiation, up to the level of a single photon of varied terrestrial or cosmic origin. The detection principles have been selected in such a way to make their implementation into practice accessible thanks to the current world standard of technical components and manufacturing technologies for these detection systems. The project�s goal is the design, verification and completion of optical structures and systems (e.g. photonic nanostructures) suitable for the detection of weak and ultra weak optic radiation, including the manufacturing technology and controls. The utilisation could be expected in the implementation of detection systems researching cosmic radiation for optic communication systems based on quantum optics, in the optical manufacturing of the modern type generally, etc. Results of the technological project part will be partly used in the construction of functional detection systems researching cosmic rays, optical communication systems built on the principle of quantum optics, etc.

1M06032 �Research centre of forming technologies � FORTECH�, 3/2006-12/2009, the researcher is Prof. Dr. Ing. Bohuslav Ma�ek, University of West Bohemia in Plze�, FS, the total costs of CZK 66.857 million, thereof CZK 60.728 million from the state budget. (Year 2008 � 2.016/1.828, 7d, the nanotechnology research share makes up 15% of the allocated sum.)

Co-researchers:
- SV�M, a.s., Praha, Ing. Ivo �ern�, PhD.
- COMTES FHT, s.r.o., Dob�any, Dr. Ing. Zby�ek Nov�
- �KODA V�zkum, s.r.o., Plze�, Ing. Ale� Sborn�
Objective of the project: The Research Centre focuses on the progressive work out, knowledge and handling of processes which should allow in future for implementation of new ideas in the area of forming and material technologies, especially of their innovative combinations. The main innovative parts and topics, which make up the central common axis of the project, are as follows: ultrafine grained structures and nanostructures, multi phase and polycomponent materials, difficult forming materials, new strategies for combining deformation and thermomechanical processes, the �materials friendly forming�, non conventional forming in the area of decreased and increased temperatures, the thixotropic forming, the managed structure development, the rapid prototyping in the area of forming, non conventional recycling of material wastes, the modelling and FEM simulations, and the non conventional material joining.

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